E-POSTER DETAIL | 11th Asia Pacific Tele Ophthalmology Society Symposium

Title
Beyond Atropine: A Novel Combined Regimen for Rapidly Progressive Myopia – Case Insights

Authors
Mingyang Hu

Presenting
Mingyang Hu

PURPOSE:
Exploring the Efficacy and Mechanisms of Difrarel Tablets, Compound Vitamin B Tablets Combined with Racemic Anisodamine Eye Drops in Controlling Accommodative Spastic Myopia and Axial Length Elongation Associated with Visual Fatigue in Adolescents.

METHODS:
Male, 12 years old, presented with blurred vision in both eyes accompanied by severe orbital soreness and photophobia. Over the past six months, SE had rapidly progressed by -0.75D. SE of -3.25D in both eyes, AL 24.85mm, BCC +1.25D. The diagnosis was mixed myopia with severe visual fatigue. A combined treatment regimen was prescribed: Difrarel Tablets (3 tablets twice daily); Compound Vitamin B Tablets (1 tablet twice daily); and instillation of 0.05% racemic anisodamine eye drops before bedtime to relieve ciliary muscle spasm.

METHODS:

Male, 12 years old, presented with blurred vision in both eyes accompanied by severe orbital soreness and photophobia. Over the past six months, SE had rapidly progressed by -0.75D. SE of -3.25D in both eyes, AL 24.85mm, BCC +1.25D. The diagnosis was mixed myopia with severe visual fatigue. A combined treatment regimen was prescribed: Difrarel Tablets (3 tablets twice daily); Compound Vitamin B Tablets (1 tablet twice daily); and instillation of 0.05% racemic anisodamine eye drops before bedtime to relieve ciliary muscle spasm.

RESULTS:
1 month post-treatment: patient’s visual fatigue score dropped 90%, accommodation sensitivity normalized. 6-month follow-up: pseudomyopia fully resolved, SE regressed to -3.00D. 18-month follow-up end: binocular SER stabilized at -3.12D (annual progression: -0.08D), axial length annual growth controlled at 0.09mm—well below age-matched physiological mean.

CONCLUSIONS:
This case confirms the superiority of the three-pronged "microcirculation improvement–neurotrophic support–spasm relief" therapy. Difrarel Tablets promote rhodopsin regeneration and increase choroidal blood flow, while B vitamins enhance metabolic function in optic nerve and retinal cells—their combination alleviates visual fatigue caused by metabolite accumulation. Racemic anisodamine specifically blocks the mechanical stimulation of accommodative spasm on axial elongation. Through multi-target intervention, this combined regimen significantly reduces visual fatigue-induced myopia progression, offering a novel, safe, and effective clinical strategy.

CONCLUSIONS:

This case confirms the superiority of the three-pronged "microcirculation improvement–neurotrophic support–spasm relief" therapy. Difrarel Tablets promote rhodopsin regeneration and increase choroidal blood flow, while B vitamins enhance metabolic function in optic nerve and retinal cells—their combination alleviates visual fatigue caused by metabolite accumulation. Racemic anisodamine specifically blocks the mechanical stimulation of accommodative spasm on axial elongation. Through multi-target intervention, this combined regimen significantly reduces visual fatigue-induced myopia progression, offering a novel, safe, and effective clinical strategy.