E-POSTER DETAIL | 11th Asia Pacific Tele Ophthalmology Society Symposium

Title
Effect of Trans-PRK combined with 0.02 % MMC on the changes in corneal density

Authors
Tianxu Pei, Lin Jin, Shifeng Fang, Lijun Zhang

Presenting
Tianxu Pei

PURPOSE:
To evaluate the effect of 0.02% mitomycin-C (MMC) on the corneal density（CD） after transepithelial photorefractive keratectomy (trans-PRK).

METHODS:
Retrospective case analysis. Selected 28 patients with 56 eyes in moderate myopia who underwent Trans-PRK surgery in our hospital. They were divided into MMC group in 28 eyes with a combination of 0.02% MMC 20s during the surgery and the control group in 28 eyes was not useing MMC. The Pentacam anterior segment analyzer was used to measured the CD in different diameter ranges and different thickness layers before and after surgery at 14d, and after surgery at 1, 3mo.

METHODS:

Retrospective case analysis. Selected 28 patients with 56 eyes in moderate myopia who underwent Trans-PRK surgery in our hospital. They were divided into MMC group in 28 eyes with a combination of 0.02% MMC 20s during the surgery and the control group in 28 eyes was not useing MMC. The Pentacam anterior segment analyzer was used to measured the CD in different diameter ranges and different thickness layers before and after surgery at 14d, and after surgery at 1, 3mo.

RESULTS:
In the zone of 0-2mm, the CD of the two groups at 14d after the surgery was higher (P<0.001 ). In the zone of 2-6mm, the CD of the two groups at 1mo and 3mo after surgery was higher (P<0.001). In the zone of 6-10mm, the CD of the two groups at 14d, 1 and 3mo after surgery was higher (P<0.001). In the layer of anterior 120 μm, the CD of the two groups at 1mo and 3mo after the surgery was decreased (P<0.01). In the middle layer, the CD of the two groups at 1mo after the surgery was decreased (P<0.01).

RESULTS:

In the zone of 0-2mm, the CD of the two groups at 14d after the surgery was higher (P<0.001 ). In the zone of 2-6mm, the CD of the two groups at 1mo and 3mo after surgery was higher (P<0.001). In the zone of 6-10mm, the CD of the two groups at 14d, 1 and 3mo after surgery was higher (P<0.001). In the layer of anterior 120 μm, the CD of the two groups at 1mo and 3mo after the surgery was decreased (P<0.01). In the middle layer, the CD of the two groups at 1mo after the surgery was decreased (P<0.01).

CONCLUSIONS:
The use of 0.02% MMC during the operation can reduce the corneal density and increase the corneal light transmittance in the early postoperative period. The occurrence and prognosis of haze can be effectively quantified by observing the changes of corneal density in different ranges in different time periods after operation.