E-POSTER DETAIL | 11th Asia Pacific Tele Ophthalmology Society Symposium

Title
脉络膜毛细血管血流面积对糖尿病性黄斑缺血的影响

Authors
yueling Cui

Presenting
yueling Cui

PURPOSE:
To investigate the association between choriocapillaris flow area (CCFA), measured by optical coherence tomography angiography (OCTA), and retinal capillary alterations in patients with diabetic macular ischemia (DMI).

METHODS:
This cross-sectional study included a total of 159 age-matched eyes, which were divided into three groups: a healthy control group (46 eyes), a diabetic group without macular ischemia (Non-DMI group, 59 eyes), and a diabetic macular ischemia group (DMI group, 54 eyes). All participants underwent optical coherence tomography angiography (OCTA). Choriocapillaris flow area (CCFA), vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone perimeter (FAZ-P), and acircularity index (FAZ-CI) were quantitatively measured. Correlation analyses were performed to evaluate the relationships between CCFA and retinal vascular parameters.

METHODS:

This cross-sectional study included a total of 159 age-matched eyes, which were divided into three groups: a healthy control group (46 eyes), a diabetic group without macular ischemia (Non-DMI group, 59 eyes), and a diabetic macular ischemia group (DMI group, 54 eyes). All participants underwent optical coherence tomography angiography (OCTA). Choriocapillaris flow area (CCFA), vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone perimeter (FAZ-P), and acircularity index (FAZ-CI) were quantitatively measured. Correlation analyses were performed to evaluate the relationships between CCFA and retinal vascular parameters.

RESULTS:
Compared with the healthy control and Non-DMI groups, CCFA was significantly reduced in the DMI group, with statistically significant differences (H(2) = 40.526, P < 0.01). Correlation analyses revealed that CCFA was positively correlated with vessel density of both SCP and DCP (SCP: H(2) = 40.526, P < 0.01; DCP: H(2) = 30.942, P < 0.001), negatively correlated with FAZ-P (H(2) = 7.841, P = 0.02), and positively correlated with FAZ-CI (H(2) = 20.3, P < 0.001)

RESULTS:

Compared with the healthy control and Non-DMI groups, CCFA was significantly reduced in the DMI group, with statistically significant differences (H(2) = 40.526, P < 0.01). Correlation analyses revealed that CCFA was positively correlated with vessel density of both SCP and DCP (SCP: H(2) = 40.526, P < 0.01; DCP: H(2) = 30.942, P < 0.001), negatively correlated with FAZ-P (H(2) = 7.841, P = 0.02), and positively correlated with FAZ-CI (H(2) = 20.3, P < 0.001)

CONCLUSIONS:
CCFA is significantly reduced in diabetic macular ischemia and is closely associated with retinal microvascular alterations, indicating concurrent retinal and choroidal microvascular impairment. CCFA may serve as a potential OCTA-based imaging biomarker for the early detection and monitoring of DMI, pending validation by longitudinal studies.